Correlation Between Circulating HIV-1 RNA and Broad HIV-1 Neutralizing Antibody Activity
نویسندگان
چکیده
منابع مشابه
HIV-1 gp41 Core with Exposed Membrane-Proximal External Region Inducing Broad HIV-1 Neutralizing Antibodies
The membrane-proximal external region (MPER) of the HIV-1 gp41 consists of epitopes for the broadly cross-neutralizing monoclonal antibodies 2F5 and 4E10. However, antigens containing the linear sequence of these epitopes are unable to elicit potent and broad neutralizing antibody responses in vaccinated hosts, possibly because of inappropriate conformation of these epitopes. Here we designed a...
متن کاملتوسعه روش NASBA-ELISA برای تشخیص HIV-1 RNA
چکید ه سابقه و هدف با شروع عفونت HIV-1 ، اولین مارکری که در خون آشکار می‌شود، RNA ویروسی می‌باشد. از میان روش‌های موجود که شناسایی RNA را هدف قرار می‌دهند؛ متداول‌ترین روش‌ها NASBA و RT-PCR هستند. NASBA مزیت‌های متعددی نسبت به RT-PCR ارایه می‌کند. در این پژوهش، واکنش NASBA در ترکیب با روش آشکارسازی آسان و حساس الایزا، برای تشخیص و آشکارسازی HIV-1 RNA مورد استفاده قرار گرفت. مواد و روش‌ه...
متن کاملResistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12.
The 2G12 mAb inhibits the infection of HIV-1 laboratory-adapted viruses at 50% inhibitory concentrations (IC(50)) ranging from 0.02 to 0.2 microg/ml when evaluated in different cell-types. However, isolates from various HIV-1 subtypes (such as clade C, D, A/E, F and group O) were not inhibited by 2G12 mAb (IC(50) >20 microg/ml). 2G12 mAb pressure in HIV-1 IIIB- and NL4.3-infected T cell culture...
متن کاملPotent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1.
Several human monoclonal antibodies (hmAbs) exhibit relatively potent and broad neutralizing activity against HIV-1, but there has not been much success in using them as potential therapeutics. We have previously hypothesized and demonstrated that small engineered antibodies can target highly conserved epitopes that are not accessible by full-size antibodies. However, their potency has not been...
متن کاملDissecting the neutralizing antibody specificities of broadly neutralizing sera from 1 HIV - 1 infected donors
234 words; Text: 7458 words 22 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.02749-06 JVI Accepts, published online ahead of print on 4 April 2007
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ژورنال
عنوان ژورنال: JAIDS Journal of Acquired Immune Deficiency Syndromes
سال: 2011
ISSN: 1525-4135
DOI: 10.1097/qai.0b013e3182100c1b